- Oleg Taktarov as Nikolai, a Russian commando from the Spetsnaz Alpha Group who was fighting in South Ossetia before finding himself on the alien planet.
- Louis Ozawa Changchien as Hanzo, a Yakuza enforcer who rarely speaks and reveals late in the film that he is missing his leftmost two fingers, having performed yubitsume.
- Mahershalalhashbaz Ali as Mombasa, a Sierra Leone Revolutionary United Front death squad soldier.
- Danny Trejo as Cuchillo, a ruthless enforcer for the Los Zetas Mexican drug cartel who carries twin submachine guns.
- Laurence Fishburne as Noland, a United States Army Air Cavalry soldier who has survived on the alien planet for multiple hunting cycles.